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The solution

Rutigliano G, Accorroni A, Zucchi R

The 677T allele encodes an enzyme that is thermolabile and less efficient at generating the 5-MTHF that is needed for both homocysteine remethylation and the generation of S-adenosyl methionine for methylation reactions MTHFR 677TT homozygotes with low folate status are at a greatly increased risk of being hyperhomocysteinemic Citation[71]